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B-Cell Binding, Capacity, Activation and Tolerance:
Analytical Results and Results from Computer Modeling

Gyan Bhanot
IBM Research and Princeton University
November 9, 2001
After a brief introduction to the immune system, I will describe some new analytic results on antibody capacity and degeneracy. Among other things, I will show why the immune system must delete/re-edit 63% of B-Cells for optimal efficiency and why memory cells are used before newly created cells in fighting disease. I will then describe some puzzling experiments on B-Cell Binding and Activation done in the mid 1980's by Dintzis et al. With an additional hypothesis about the rate of endocytosis, I will describe how we resolve these puzzles via computer simulation.

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