of the Immune System Response: A Cellular Automaton
Italy Physics Department
University of Roma
"La Sapienza", Roma, Italy
December 14, 1999
We discuss the collective dynamics of of the
immune system response as described by the Celada-Seiden
The dynamic nature of affinity maturation, i.e.
the learning process behind the Immune System
ability to withstand pathogen agents (Antigens)
is explored by means of large-scale computer simulations.
These simulations suggest that affinity maturation
proceeds through a sequential cascade from low
to high-affinity individuals (B-cells) characterized
by a definite time-arrow.
The robustness of the 'learning cascade' against
parameter changes, such as size of the Immune
System repertoire, cell density and presence/absence
of somatic hypermutation is discussed and commented